Indacaterol maleate
CAS No. 753498-25-8
Indacaterol maleate( —— )
Catalog No. M15866 CAS No. 753498-25-8
Indacaterol Maleate is an ultra-long-acting β-adrenoceptor agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
10MG | 27 | In Stock |
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25MG | 43 | In Stock |
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50MG | 61 | In Stock |
|
100MG | 88 | In Stock |
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200MG | 133 | In Stock |
|
500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameIndacaterol maleate
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NoteResearch use only, not for human use.
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Brief DescriptionIndacaterol Maleate is an ultra-long-acting β-adrenoceptor agonist.
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DescriptionIndacaterol Maleate is an ultra-long-acting β-adrenoceptor agonist.
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In VitroCell Viability Assay Cell Line:HT1080 cells (constitutively express MMP-9)Concentration:1, 2.5, 5, 10 μM Incubation Time:12 h (pretreat)Result:Significantly suppressed MMP-9 mRNA expression in the 2.5 to 10 μM range.Cell Migration Assay Cell Line:HT1080 cells (constitutively express MMP-9)Concentration:10 μM Incubation Time:6 h (pretreat for 2 h, then incubat with TNF-α for 4 h)Result:Significantly reduced cell migration of fibrosarcoma and inhibited HT1080 cell migration in the zone of wound healing.Western Blot Analysis Cell Line:HT1080 cells Concentration:1, 2.5, 5, 10 μM Incubation Time:2.5 h (pretreat for 2 h, then incubat with TNF-α for 0.5 h) Result: Suppressed TNF-α induced the phosphorylation of IκBα and IKKα/β (the upstream activators of NF-κB).Inhibited TNF-α-induced NF-κB nuclear translocation when at 5 and 10 μM.Suppressed TNF-α-induced MMP-9 enzyme activity and decreased MMP-9 protein levels in a dose-dependent manner in the 2.5 to 10 μM range.
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In VivoAnimal Model:Male Wistar rats (225-250 g; myocardial infarction (MI) rat model of heart failure (HF)).Dosage:0.3 mg/kg Administration:In animal drinking water; sinle daily for 15 weeks Result:Significantly reduced both mean arterial blood pressure and heart rate.Increased both systolic and diastolic LVID where in HF, and reversed the decreased ejection fraction (%) values.Significantly reduced the infarct size, and catecholamine values to basal levels.Significantly increased β1 mRNA expression and cardiac cAMP levels in respect to HF.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetAdrenergic Receptor
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Recptorβ1-adrenoceptor| β2-adrenoceptor
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number753498-25-8
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Formula Weight508.56
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Molecular FormulaC24H28N2O3
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Purity>98% (HPLC)
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SolubilityDMSO: 102 mg/mL (200.56 mM)
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SMILESCCC1=C(C=C2CC(CC2=C1)NC[C@@H](C3=C4C=CC(=O)NC4=C(C=C3)O)O)CC.C(=C\C(=O)O)\C(=O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Battram C, et al. J Pharmacol Exp Ther, 2006, 317(2), 762-770.
molnova catalog
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