Indacaterol maleate

CAS No. 753498-25-8

Indacaterol maleate( —— )

Catalog No. M15866 CAS No. 753498-25-8

Indacaterol Maleate is an ultra-long-acting β-adrenoceptor agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 27 In Stock
25MG 43 In Stock
50MG 61 In Stock
100MG 88 In Stock
200MG 133 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Indacaterol maleate
  • Note
    Research use only, not for human use.
  • Brief Description
    Indacaterol Maleate is an ultra-long-acting β-adrenoceptor agonist.
  • Description
    Indacaterol Maleate is an ultra-long-acting β-adrenoceptor agonist.
  • In Vitro
    Cell Viability Assay Cell Line:HT1080 cells (constitutively express MMP-9)Concentration:1, 2.5, 5, 10 μM Incubation Time:12 h (pretreat)Result:Significantly suppressed MMP-9 mRNA expression in the 2.5 to 10 μM range.Cell Migration Assay Cell Line:HT1080 cells (constitutively express MMP-9)Concentration:10 μM Incubation Time:6 h (pretreat for 2 h, then incubat with TNF-α for 4 h)Result:Significantly reduced cell migration of fibrosarcoma and inhibited HT1080 cell migration in the zone of wound healing.Western Blot Analysis Cell Line:HT1080 cells Concentration:1, 2.5, 5, 10 μM Incubation Time:2.5 h (pretreat for 2 h, then incubat with TNF-α for 0.5 h) Result: Suppressed TNF-α induced the phosphorylation of IκBα and IKKα/β (the upstream activators of NF-κB).Inhibited TNF-α-induced NF-κB nuclear translocation when at 5 and 10 μM.Suppressed TNF-α-induced MMP-9 enzyme activity and decreased MMP-9 protein levels in a dose-dependent manner in the 2.5 to 10 μM range.
  • In Vivo
    Animal Model:Male Wistar rats (225-250 g; myocardial infarction (MI) rat model of heart failure (HF)).Dosage:0.3 mg/kg Administration:In animal drinking water; sinle daily for 15 weeks Result:Significantly reduced both mean arterial blood pressure and heart rate.Increased both systolic and diastolic LVID where in HF, and reversed the decreased ejection fraction (%) values.Significantly reduced the infarct size, and catecholamine values to basal levels.Significantly increased β1 mRNA expression and cardiac cAMP levels in respect to HF.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    Adrenergic Receptor
  • Recptor
    β1-adrenoceptor| β2-adrenoceptor
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    753498-25-8
  • Formula Weight
    508.56
  • Molecular Formula
    C24H28N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 102 mg/mL (200.56 mM)
  • SMILES
    CCC1=C(C=C2CC(CC2=C1)NC[C@@H](C3=C4C=CC(=O)NC4=C(C=C3)O)O)CC.C(=C\C(=O)O)\C(=O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Battram C, et al. J Pharmacol Exp Ther, 2006, 317(2), 762-770.
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